Cubs at Padres Prediction: Odds, expert picks, starting pitchers, betting trends and stats for April 16

Its Wednesday, April 16 and the Cubs (12-8) are in San Diego for the final game of their three-game series against the Padres (14-4).

Matthew Boyd is slated to take the mound for Chicago against Nick Pivetta for San Diego.

Last night the Cubs evened the series at one game apiece with a 2-1 win in ten innings. Ryan Pressley got his first win with Chicago with a perfect ninth inning and Caleb Thielbar notched his first save retiring the Padres in the tenth.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Cubs at Padres

• Date: Wednesday, April 16, 2025
• Time: 4:10PM EST
• Site: Petco Park
• City: San Diego, CA
• Network/Streaming: MARQ, SDPA

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Cubs at the Padres

The latest odds as of Wednesday:

• Moneyline: Cubs (+101), Padres (-121)
• Spread: Padres -1.5
• Total: 7.0 runs

Probable starting pitchers for Cubs at Padres

• Pitching matchup for April 16, 2025: Matthew Boyd vs. Nick Pivetta
  • Cubs: Matthew Boyd (1-1, 1.59 ERA)
    Last outing: 4/11 at Dodgers – 6IP, 3ER, 4H, 3BB, 7Ks
  • Padres: Nick Pivetta (2-1, 1.59 ERA)
    Last outing: 4/11 vs. Colorado – 7IP. 0ER, 3H, 1BB, 10Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Cubs at Padres

• The Padres are now 13-5 on the Run Line this season
• Cubs’ games are 13-6-1 to the OVER this season
• Fernando Tatis Jr. is riding a 5-game hitting streak (7-25) but his batting average has actually dropped during the streak to .354
• With two more hits yesterday, Kyle Tucker is hitting .313

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for today’s game between the Cubs and the Padres

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday’s game between the Cubs and the Padres:

• Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Chicago Cubs at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)